MovDisordV3, Main, Exploration, bibRecord, 001071

Living on the Edge With Too Many Mouths to Feed: Why Dopamine Neurons Die

Identifieur interne : 001071 ( Main/Exploration ); précédent : 001070; suivant : 001072

Living on the Edge With Too Many Mouths to Feed: Why Dopamine Neurons Die

Auteurs : J. Paul Bolam [Royaume-Uni] ; Eleftheria K. Pissadaki [Royaume-Uni, Grèce]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0423957

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux, Dopamine, Neurone.

English descriptors

KwdEn :
- Animals, Axons (physiology), Cell Death, Dopamine, Dopaminergic Neurons (cytology), Dopaminergic Neurons (physiology), Humans, Nervous system diseases, Neuron, Parkinson Disease (pathology), Parkinson Disease (physiopathology), Substantia Nigra (cytology), Synapses (physiology).
MESH :
- cytology : Dopaminergic Neurons, Substantia Nigra.
- pathology : Parkinson Disease.
- physiology : Axons, Dopaminergic Neurons, Synapses.
- physiopathology : Parkinson Disease.
- Animals, Cell Death, Humans.

Abstract

Although genes, protein aggregates, environmental toxins, and other factors associated with Parkinson's disease (PD) are widely distributed in the nervous system and affect many classes of neurons, a consistent feature of PD is the exceptional and selective vulnerability of dopamine (DA) neurons of the SNc. What is it about these neurons, among all other neurons in the brain, that makes them so susceptible in PD? We hypothesize that a major contributory factor is the unique cellular architecture of SNc DA neuron axons. Their large, complex axonal arbour puts them under such a tight energy budget that it makes them particularly susceptible to factors that contribute to cell death, including unique molecular characteristics associated with SNc DA neurons and nonspecific, nervous-system-wide factors.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504389

Affiliations:

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Movement Disorders (revue)

Living on the Edge With Too Many Mouths to Feed: Why Dopamine Neurons Die

Living on the Edge With Too Many Mouths to Feed: Why Dopamine Neurons Die

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.